At the recent OSA BIOMED 2016 conference, a poster co-authored by Cephalogics, Washington University, and Triple Ring Technologies was presented regarding the development of a compact high-density diffuse optical tomography (DOT) system for cerebral oxygenation and perfusion imaging on the bedside and demonstrated its insensitivity to the superficial layer in a custom two-layered blood phantom.
Patients with a variety of neural disease states including cerebral hemorrhage, ischemia, and head trauma are at risk of impaired cerebral perfusion. Reliable, accurate, continuous, bedside imaging of cerebral tissue oxygen saturation (StO2) could help clinicians manage perfusion in these patients. However, demonstrating the accuracy of cerebral StO2 images in vivo is unfeasible since no reference standard exists.
Measurements in tissue mimicking phantoms provide a reasonable first-step towards verification of system performance and characterization. Intralipid (IL) and ink phantoms have been commonly used to verify measurements of optical properties [1,2]; blood phantoms have been used to better mimic physiology and incorporate physiologically relevant absorption and scattering spectra ; other phantom experiments have included multi-layer designs to approximate the layered composition of the human head.
Combining these ideas, we have designed a two-layered blood phantom for verification of blood oxygen saturation (SO2) measurements in the “brain” layer. In the poster, we reported preliminary measurements on this phantom using a new compact DOT system for quantitative, non-invasive, continuous bedside imaging of cerebral oxygenation and perfusion in patients with cerebrovascular disease.
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Authors: Bertan Hallacoglu [A], Jason W. Trobaugh [A-B], Kate L. Bechtel [C], Chandran V. Seshagiri [A]
A. Cephalogics, LLC
B. Department of Electrical and Systems Engineering, Washington University in St. Louis, MO
C. Triple Ring Technologies, Inc.
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