A scientist in a lab coat and gloves examines a vial near a Beckman Coulter Life Sciences Cytoflex flow cytometry analyzer, with data from algorithm development displayed on a computer screen in a modern laboratory setting.
Key Innovation By fusing optical science with data engineering, we gave a mature instrument platform the analytical flexibility to outpace dedicated software rivals.
Beckman Coulter logo featuring a stylized circular design next to the company name in bold, uppercase letters.

Flow Cytometer Data Analysis

Client

Beckman Coulter Life Sciences

Practice Areas

Industrial TechBio & Life Sciences

Core Disciplines

Software Engineering AI & Advanced Algorithms Molecular & Cell Biology
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Overview

The CytoFLEX platform from Beckman Coulter Life Sciences is a market-leading flow cytometry platform designed to provide high sensitivity, strong resolution, and flexible configuration options across a wide range of applications. Built to support advanced sample analysis and regulatory workflows, the platform integrates CytExpert acquisition and analysis software and supports features such as multi-color detection and high-throughput processing.

To expand the platform’s analytical capabilities and strengthen its competitive position against third-party software solutions, Beckman Coulter Life Sciences partnered with Triple Ring to develop advanced data analysis algorithms supporting new high-value customer use cases.

Challenge

A key driver of the CytoFLEX platform’s longstanding market success is its sophisticated data analysis software suite, which allows users to predict unknown properties of their test samples. At project initiation, Triple Ring was tasked with designing algorithms to expand the number of high-value customer use cases from two to ten.

Beckman Coulter Life Sciences sought to capture market value held by third-party solutions while maintaining performance, flexibility, and speed of development across multiple technical disciplines.

Solution

Triple Ring applied cross-disciplinary expertise in optics, simulation, and system design to improve performance and manufacturability.

Key technical efforts included:

  • Optimizing optical subsystem design to improve signal sensitivity
  • Developing analytical models to predict system performance across configurations
  • Supporting integration of acquisition and analysis software workflows
  • Refining system architecture to improve manufacturability and yield
Three white and blue laboratory analyzers of varying sizes are arranged in a row on a plain background. The devices have a modern design with a hexagonal dot pattern on the front panels.

Outcome

The expanded analytics capabilities enabled Beckman Coulter Life Sciences to flexibly support multiple high-value customer use cases, strengthening the competitive position of the CytoFLEX platform and enabling future growth.

The collaboration produced valuable intellectual property and enhanced software capabilities that positioned the platform to capture market share previously held by third-party solutions.

Triple Ring Talent

The Story Behind the Collaboration

At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team blended deep optics knowledge with advanced algorithm development, data science, and software engineering — expanding the CytoFLEX platform’s analytical capabilities from two to ten high-value customer use cases and capturing market share previously held by third-party solutions.

Daniel and Hailey collaborated with many talented colleagues across Triple Ring and Beckman Coulter on this project.

Meet our team
A portrait of Daniel Badali, a smiling man with glasses and a beard against a gray background.

Daniel Badali, PhD

Optics & Applied Physics

Dr. Daniel Badali brings deep expertise in advanced algorithms, optics, and radiation physics. His work bridges software and hardware, enabling complex simulation, imaging, and sterilization technologies that help turn sophisticated concepts into reliable medical solutions.

A portrait of Hailey Gryka, a woman with glasses and long curly hair smiling against a gray background.

Hailey Gryka

Bioinstrumentation & Data Science

Hailey Gryka brings expertise at the intersection of bioinstrumentation and data science. Her work spans device design, data processing, and system validation, helping teams move seamlessly from early concepts to manufacturable, reliable solutions.

A lab technician in a white coat holds blood samples near laboratory equipment, showcasing the legacy IVD product modernization process while ensuring 510(k) compliance.
Key Innovation By reverse engineering lost institutional knowledge and validating component equivalency, we unlocked a Special 510(k) pathway without redesigning a full platform.

IVD Platform Refresh

Client

Fortune 500 IVD Company

Practice Areas

TechBio & Life Sciences

Core Disciplines

Software Engineering Molecular & Cell Biology Mechanical Engineering Transfer to Manufacture Electrical Engineering Embedded Systems
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Overview

A Fortune 500 diagnostics manufacturer worked with Triple Ring to modernize a legacy in vitro diagnostic (IVD) platform facing component obsolescence and software limitations. The project focused on refreshing the system architecture while maintaining regulatory equivalency with an existing FDA-cleared product.

The resulting platform replaced obsolete hardware, migrated legacy software, and introduced updated industrial design elements while preserving compatibility with established manufacturing and regulatory pathways.

Challenge

The client faced the obsolescence of critical hardware components, including single-board computers and microcontrollers, within an existing diagnostic platform. Compounding the challenge, original firmware source code was unavailable, and institutional knowledge associated with the system had diminished over time.

In addition to restoring functionality, the refreshed system needed to maintain regulatory equivalence to the original device in order to qualify for a Special 510(k) submission. This requirement demanded careful reverse engineering, system validation, and modernization without introducing unintended performance deviations.

Close-up of a computer hard drive circuit board, showcasing blue circuitry and an attached circular component with orange connectors, reminiscent of the precision needed in legacy IVD product modernization and 510(k) compliance.
A person is sitting at a desk using a laptop and monitor, both displaying lines of code. A tablet with a blank page is also on the desk, suggesting plans for legacy IVD product modernization.

Solution

Triple Ring implemented a structured modernization strategy combining reverse engineering, hardware redesign, and software migration. The development effort focused on preserving functional equivalency while introducing modern components and improving long-term maintainability.

Development efforts included:

  • Reverse-engineering legacy hardware and firmware to recover system functionality and requirements
  • Migrating existing software to a modern operating system architecture
  • Replacing obsolete components while maintaining compatibility with legacy subsystems
  • Updating mechanical and electrical subassemblies to support manufacturing continuity
  • Preparing validation and documentation packages supporting regulatory equivalence requirements

Outcome

Triple Ring delivered a fully refreshed IVD platform supported by a comprehensive regulatory submission package demonstrating equivalency to the original FDA-cleared device. The updated system maintained functional continuity while addressing long-term hardware and software sustainability.

The refreshed design integrated seamlessly into existing manufacturing workflows, enabling uninterrupted production and maintaining cost targets. The modernization effort positioned the platform for continued market competitiveness while ensuring regulatory compliance and operational reliability.

Triple Ring Talent

The Story Behind the Innovation

At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined reverse engineering, embedded systems, software migration, regulatory strategy, and industrial design expertise to modernize a legacy IVD platform — restoring long-term sustainability while maintaining full regulatory equivalency with the original FDA-cleared device.

Rob and Anne collaborated with many talented colleagues across Triple Ring on this project.

Meet our team
A portrait of Robert de Saint Phalle, a smiling man wearing a blue shirt, with a blurred background.

Robert de Saint Phalle

Interdisciplinary Product Design

Robert de Saint Phalle shapes product design strategies that connect engineering, user experience, and emerging technologies. His work helps teams translate complex ideas into thoughtful, functional products that bring new technologies to life.

A photo of Anne Preut, a woman with wavy brown hair smiling, wearing a green top and small gold hoop earrings, against a blurred gray background.

Anne Preut

Biomedical & Systems Engineering

Anne Preut leads systems engineering efforts that integrate hardware, firmware, assays, and fluidics across complex diagnostic technologies. Her work aligns cross-functional teams throughout the development lifecycle, helping ensure systems perform reliably from early feasibility through production.