Key Innovation
By integrating algorithms to compensate for variable tissue morphologies within a compact handheld form factor, we unlocked reliable, real-time StO₂ measurement directly inside the surgical theater.
Real-Time Tissue Oxygenation Status
Client
ViOptix
Practice Areas
Core Disciplines
Overview
ViOptix collaborated with Triple Ring to design and develop the Intra.Ox™, a non-invasive, handheld tissue oxygenation monitor designed for use inside the surgical theater. The device enables real-time measurement of tissue oxygenation, helping surgeons assess tissue viability and make informed decisions during procedures.
By combining optical sensing technology with advanced algorithms and a portable handheld design, the system supports improved surgical workflows and enhances clinical decision-making during tissue transfer procedures.
Challenge
ViOptix sought to develop a quantitative tissue oxygenation monitor capable of delivering real-time, highly sensitive measurements in a surgical environment. The system needed to be easy to use, reliable, and capable of generating unlimited readings throughout a surgical case.
Key technical challenges included:
- Designing an easy-to-use multi-wavelength tissue oximeter
- Developing smart algorithms to compensate for variable tissue morphologies
- Creating a compact handheld form factor suitable for surgical use
- Supporting reusable packaging and surgical workflows
- Ensuring consistent performance across varying tissue conditions
In addition, the system needed to accurately capture oxygen concentration in resected tissue while minimizing artifacts caused by surrounding tissue components.
Real-Time Tissue Oxygenation Status
Overview
ViOptix collaborated with Triple Ring to design and develop the Intra.Ox™, a non-invasive, handheld tissue oxygenation monitor designed for use inside the surgical theater. The device enables real-time measurement of tissue oxygenation, helping surgeons assess tissue viability and make informed decisions during procedures.
By combining optical sensing technology with advanced algorithms and a portable handheld design, the system supports improved surgical workflows and enhances clinical decision-making during tissue transfer procedures.
Challenge
ViOptix sought to develop a quantitative tissue oxygenation monitor capable of delivering real-time, highly sensitive measurements in a surgical environment. The system needed to be easy to use, reliable, and capable of generating unlimited readings throughout a surgical case.
Key technical challenges included:
- Designing an easy-to-use multi-wavelength tissue oximeter
- Developing smart algorithms to compensate for variable tissue morphologies
- Creating a compact handheld form factor suitable for surgical use
- Supporting reusable packaging and surgical workflows
- Ensuring consistent performance across varying tissue conditions
In addition, the system needed to accurately capture oxygen concentration in resected tissue while minimizing artifacts caused by surrounding tissue components.
Client
ViOptix
Practice Areas
Core Disciplines
Solution
Triple Ring and ViOptix worked side-by-side to invent subsystem- and system-level solutions that enabled reliable real-time tissue oxygenation monitoring. The development effort spanned concept generation through clinical validation, with a strong emphasis on modeling, algorithm design, and usability.
Triple Ring applied deep clinical and technical expertise to accelerate development while supporting the needs of a virtual startup environment. Complex modeling techniques, including Monte Carlo simulations, were used to evaluate optical performance and optimize system behavior early in the design process.
Engineering efforts focused on:
- Designing multi-wavelength optical sensing systems capable of detecting tissue oxygenation levels
- Developing algorithms that compensated for variability in tissue characteristics
- Optimizing handheld system architecture to support surgical usability
- Validating measurement accuracy across simulated clinical environments
Outcome
The ViOptix Intra.Ox technology received FDA clearance after demonstrating its ability to produce accurate, instantaneous estimates of percent saturated oxygen (StO₂) without requiring capital equipment or dye injection.
The device is now used during tissue transfer surgeries to support real-time assessment of tissue viability, enabling earlier intervention and improving both clinical and financial outcomes. The program progressed from concept to clinical validation and FDA 510(k) clearance in approximately 18 months, demonstrating the efficiency of the collaborative development approach.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined advanced optical modeling, Monte Carlo simulation, algorithm development, and user-centered device design to bring a first-of-its-kind handheld tissue oxygenation monitor from concept to FDA clearance in just 18 months.
Jeremy and Nick collaborated with many talented colleagues across Triple Ring and ViOptix on this project.
Nick Hawson
Medical Device Strategy & Program Leadership
With 25 years spanning engineering, program leadership, and innovation consulting, Nick has helped bring groundbreaking medical technologies to market for companies ranging from early-stage startups to global blue-chip firms.
Jeremy Ford, PhD
Biomedical Optics & Physiological Sensing
Dr. Jeremy Ford brings a decade of biomedical optics expertise — from tissue-illumination systems and physiological sensing to optical-thermal simulation and neural inhibition — backed by a Vanderbilt PhD and extensive peer-reviewed research.
Key Innovation
By rethinking robotic architecture from first principles, we unlocked reliable, precise motion control inside the challenging electromagnetic environment of MRI.
MRI-Compatible Robotics
Client
AiM Medical Robotics
Practice Areas
Core Disciplines
Overview
AiM Medical Robotics engaged Triple Ring to develop a portable robotic system capable of performing neurosurgical procedures simultaneously with magnetic resonance imaging (MRI).
The resulting prototype established the technical foundation for an MRI-compatible robotic platform designed to support image-guided neurosurgery.
Challenge
MRI environments rely on strong magnetic fields that prohibit the use of ferromagnetic materials commonly found in traditional robotic systems. Additionally, the limited physical space inside MRI systems imposed strict form factor constraints.
These requirements demanded innovative design strategies to enable reliable robotic motion and positioning inside the MRI environment.
Solution
Triple Ring applied first-principles engineering and multidisciplinary design expertise to create an MRI-compatible robotic system.
Key elements of the solution included:
- Design of multi-axis robotic systems optimized for MRI environments
- Application of MRI physics principles to guide system architecture
- Development of MRI-compatible components and assemblies
- Rapid prototyping and testing to validate system performance
- Engineering solutions addressing constrained spatial and material limitations
MRI-Compatible Robotics
Overview
AiM Medical Robotics engaged Triple Ring to develop a portable robotic system capable of performing neurosurgical procedures simultaneously with magnetic resonance imaging (MRI).
The resulting prototype established the technical foundation for an MRI-compatible robotic platform designed to support image-guided neurosurgery.
Challenge
MRI environments rely on strong magnetic fields that prohibit the use of ferromagnetic materials commonly found in traditional robotic systems. Additionally, the limited physical space inside MRI systems imposed strict form factor constraints.
These requirements demanded innovative design strategies to enable reliable robotic motion and positioning inside the MRI environment.
Solution
Triple Ring applied first-principles engineering and multidisciplinary design expertise to create an MRI-compatible robotic system.
Key elements of the solution included:
- Design of multi-axis robotic systems optimized for MRI environments
- Application of MRI physics principles to guide system architecture
- Development of MRI-compatible components and assemblies
- Rapid prototyping and testing to validate system performance
- Engineering solutions addressing constrained spatial and material limitations
Client
AiM Medical Robotics
Practice Areas
Core Disciplines
Outcome
The collaboration produced a prototype robotic system with four degrees of freedom, establishing the basis for AiM Medical Robotics’ MRI-compatible neurosurgical platform.
The system demonstrated the feasibility of robotic-assisted neurosurgery within MRI environments and enabled further development of image-guided surgical technologies.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team applied MRI physics, multidisciplinary robotic design, and rapid prototyping to develop a four-axis robotic system capable of performing neurosurgical procedures inside a live MRI environment.
Chris and Chris collaborated with many talented colleagues across Triple Ring and AiM Medical Products on this project.
Chris Mitchell, PhD
Bio and Electrical Engineering & Program Management
Dr. Chris Mitchell brings deep experience leading multidisciplinary teams developing complex imaging and medical device systems. His work focuses on guiding technical programs from concept through implementation, helping translate advanced technologies into reliable, real-world solutions.
Chris Todd
Mechanical Engineering
Chris Todd focuses on biomedical diagnostics and precision instrumentation, integrating fluidics, optics, and mechanical systems. His work supports the development of regulated medical technologies from early concepts through manufacturing, helping teams deliver reliable diagnostic solutions at scale.
Key Innovation
By inverting the conventional radiotherapy model, and keeping the beam fixed while rotating the patient, we enabled a compact, upright treatment platform without sacrificing clinical precision.
Upright Radiation Therapy
Client
Leo Cancer Care
Practice Areas
Core Disciplines
Overview
Leo Cancer Care worked with Triple Ring to design a computed tomography (CT) imaging system supporting a novel radiation therapy concept that enables treatment in a natural, upright seated position. The system integrates imaging and patient positioning into a single device, allowing patients to be scanned in both upright and lying positions.
This platform introduces a new approach to radiotherapy delivery by improving patient comfort, positioning accuracy, and overall treatment workflow.
Challenge
Leo Cancer Care sought to develop a radiation therapy system capable of imaging and positioning patients in an upright configuration while maintaining the precision and safety required for clinical use. The concept required rethinking traditional radiotherapy architectures, including replacing large rotating gantries with a fixed-beam, slow patient rotation strategy.
Achieving this capability required overcoming mechanical, imaging, and system integration challenges while ensuring reliable clinical performance across multiple operating modes.
Upright Radiation Therapy
Overview
Leo Cancer Care worked with Triple Ring to design a computed tomography (CT) imaging system supporting a novel radiation therapy concept that enables treatment in a natural, upright seated position. The system integrates imaging and patient positioning into a single device, allowing patients to be scanned in both upright and lying positions.
This platform introduces a new approach to radiotherapy delivery by improving patient comfort, positioning accuracy, and overall treatment workflow.
Challenge
Leo Cancer Care sought to develop a radiation therapy system capable of imaging and positioning patients in an upright configuration while maintaining the precision and safety required for clinical use. The concept required rethinking traditional radiotherapy architectures, including replacing large rotating gantries with a fixed-beam, slow patient rotation strategy.
Achieving this capability required overcoming mechanical, imaging, and system integration challenges while ensuring reliable clinical performance across multiple operating modes.
Client
Leo Cancer Care
Practice Areas
Core Disciplines
Solution
Triple Ring applied expertise in radiotherapy physics, imaging systems, and mechanical engineering to design a gantry architecture supporting upright and traditional patient positioning. Close collaboration enabled integration of multiple subsystems into a unified clinical platform.
Key engineering efforts included:
- Designing multi-axis motion systems that supported upright and reclined patient positioning
- Applying radiotherapy physics expertise to guide system architecture
- Using advanced modeling and simulation tools to validate mechanical alignment and imaging accuracy
- Integrating imaging and positioning subsystems into a unified platform
Outcome
The collaboration resulted in an innovative gantry design supporting upright radiation therapy workflows and enabling alternative approaches to traditional radiotherapy systems.
The platform advanced the development of upright radiation therapy as a viable treatment approach, supporting improved patient comfort and positioning accuracy.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team applied radiotherapy physics, large-scale mechanical design, and systems integration expertise to develop a novel gantry architecture enabling patients to receive radiation therapy in a natural, upright seated position.
Tachi and Tobias collaborated with many talented colleagues across Triple Ring and Leo Cancer Care on this project.
Tachi Callas
Mechanical Engineering
Tachi Callas leads mechanical engineering teams developing complex medical technologies across the full product lifecycle. His work helps transform innovative device concepts into manufacturable systems that support advanced surgical and therapeutic applications.
Tobias Funk, PhD
Experimental Physics & Instrumentation
Dr. Tobias Funk develops advanced instrumentation that applies ionizing radiation to scientific and medical challenges. His work spans imaging, simulation, and system design, helping translate complex physical principles into practical technologies used in real-world environments.
Key Innovation
By combining microfluidic lab-on-a-chip technology and portable breath capture hardware, we brought clinical-grade THC detection out of the laboratory and into the hands of law enforcement and employers.
Cannabis Breathalyzer System
Client
Hound Labs
Practice Areas
Core Disciplines
Overview
Hound Labs engaged Triple Ring to invent a portable breath analyzer capable of detecting recent marijuana use. The system was developed to support point-of-use testing in law enforcement and workplace environments requiring reliable impairment detection.
Starting from an early concept sketch, Triple Ring collaborated with Hound Labs to develop a high-sensitivity breathalyzer platform combining chemical detection and portable instrumentation technologies.
Challenge
The system needed to detect Δ-9 THC in exhaled breath with clinical-grade sensitivity while maintaining portability and reliability in field conditions.
In addition to engineering challenges, the project required validation of THC pharmacodynamics in breath, including generation of peer-reviewed scientific evidence supporting detection feasibility.
Cannabis Breathalyzer System
Overview
Hound Labs engaged Triple Ring to invent a portable breath analyzer capable of detecting recent marijuana use. The system was developed to support point-of-use testing in law enforcement and workplace environments requiring reliable impairment detection.
Starting from an early concept sketch, Triple Ring collaborated with Hound Labs to develop a high-sensitivity breathalyzer platform combining chemical detection and portable instrumentation technologies.
Challenge
The system needed to detect Δ-9 THC in exhaled breath with clinical-grade sensitivity while maintaining portability and reliability in field conditions.
In addition to engineering challenges, the project required validation of THC pharmacodynamics in breath, including generation of peer-reviewed scientific evidence supporting detection feasibility.
Client
Hound Labs
Practice Areas
Core Disciplines
Solution
Triple Ring assembled multidisciplinary development teams to design and validate a fully integrated breath analysis platform combining microfluidic sampling and portable device technologies.
Development efforts included:
- Designing a portable breath capture device optimized for reliable sample collection
- Engineering microfluidic lab-on-a-chip cartridges supporting sensitive compound detection
- Integrating control station hardware capable of processing and analyzing captured samples
- Supporting validation activities that produced peer-reviewed pharmacodynamic data
- Developing prototype systems suitable for demonstration, testing, and continued product development
Outcome
Triple Ring delivered fully functioning prototype systems consisting of a breath capture device, control station, and microfluidic cartridges.
The system produced clinical-grade data at the point of use, supporting detection of recent marijuana use and enabling development of a first-in-class breath-based detection platform.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined microfluidic engineering, biological sensing, portable instrumentation, and clinical validation expertise to develop a first-in-class breath-based THC detection platform capable of delivering clinical-grade results at the point of use.
David and Kevin collaborated with many talented colleagues across Triple Ring and Hound Labs on this project.
David Shack, PhD
Mechanical Engineering & Applied Sciences
Dr. David Shack directs the development of complex scientific measurement and analysis systems across multidisciplinary teams. His work integrates algorithms, software, fluidics, and optical technologies, helping advance tools that support precision research and clinical applications.
Kevin Limtao
Biomedical & Systems Engineering
Kevin Limtao connects system requirements, architecture, and integration across complex medical and diagnostic technologies. His work helps teams align design, risk, and performance throughout the development lifecycle, ensuring systems function reliably from early concepts through deployment.
Key Innovation
By coupling high-speed laser-based optical imaging with machine learning workflows, we compressed oncology tissue analysis timelines from days to minutes — directly inside the OR.
Intra-Operative Tissue Pathology
Client
BlackLight Surgical
Core Disciplines
Overview
BlackLight Surgical engaged Triple Ring to develop a high-speed biochemical imaging platform designed for intra-operative tissue analysis. The system leveraged picosecond pulsing laser technology and machine learning workflows to enable rapid tissue identification during surgical procedures.
The resulting platform supports real-time clinical decision making by allowing clinicians to distinguish between normal and diseased tissue directly in the operating suite.
Challenge
The system required integration of advanced optical imaging technology capable of performing rapid biochemical analysis during surgery. Reliable performance was required across demanding clinical environments and complex workflows.
Delivering this capability required precise integration of optical, mechanical, software, and machine learning systems into a clinically deployable architecture.
Intra-Operative Tissue Pathology
Overview
BlackLight Surgical engaged Triple Ring to develop a high-speed biochemical imaging platform designed for intra-operative tissue analysis. The system leveraged picosecond pulsing laser technology and machine learning workflows to enable rapid tissue identification during surgical procedures.
The resulting platform supports real-time clinical decision making by allowing clinicians to distinguish between normal and diseased tissue directly in the operating suite.
Challenge
The system required integration of advanced optical imaging technology capable of performing rapid biochemical analysis during surgery. Reliable performance was required across demanding clinical environments and complex workflows.
Delivering this capability required precise integration of optical, mechanical, software, and machine learning systems into a clinically deployable architecture.
Client
BlackLight Surgical
Core Disciplines
Solution
Triple Ring assembled multidisciplinary engineering and scientific teams to design and integrate the imaging platform using structured development and validation methodologies.
Technical execution focused on:
- Integrating laser-based optical imaging technologies capable of rapid tissue analysis
- Developing machine learning workflows that supported real-time tissue classification
- Using simulation and modeling tools to guide system design and performance optimization
- Establishing ISO 13485-compliant design and documentation processes
Outcome
Triple Ring delivered a fully integrated intra-operative biochemical imaging platform supporting clinical studies and real-time tissue visualization.
The system was developed to ISO 13485 standards and documented within a Quality Management System transferred to BlackLight Surgical, enabling deployment of advanced intra-operative imaging workflows.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined high-speed laser optical imaging, machine learning, mechanical engineering, and quality systems expertise to develop a fully integrated intra-operative tissue analysis platform capable of distinguishing healthy from diseased tissue in real time.
Todd, Cameran, and Shehadeh collaborated with many talented colleagues across Triple Ring and BlackLight Surgical on this project.
Todd Harris, PhD
Physics & Optical Science
Dr. Todd Harris applies expertise in optics and imaging physics to the development of advanced sensing and illumination technologies. His work combines optical modeling with system design, helping teams translate complex physical principles into dependable, high-performance solutions.
Cameran Casale
Bioengineering
Cameran Casale contributes to the development of imaging, microfluidic, and diagnostic technologies across multidisciplinary programs. Her work supports system integration and testing efforts, helping teams refine complex devices for reliable performance in research and clinical environments.
Shehadeh Dajani
Aerospace & Mechanical Engineering
Shehadeh Dajani supports the development of safety-critical embedded systems used in regulated medical technologies. His work spans software and system integration across feasibility, clinical, and production stages, helping ensure reliable performance throughout the development lifecycle.
Key Innovation
By coupling wearable optics with injectable dyes, we enabled continuous, non-invasive kidney monitoring without repeated blood draws or lab visits.
Transdermal GFR Measurement
Client
MediBeacon
Practice Areas
Core Disciplines
Overview
MediBeacon partnered with Triple Ring to develop a photonics-based transdermal detection system designed to measure kidney function using fluorescent tracer technology. The system enables non-invasive monitoring of intravenously injected tracers to generate clinically actionable measurements of glomerular filtration rate (GFR).
The resulting wearable detection platform integrates optical sensing and physiological measurement technologies to support real-time kidney function assessment in clinical environments.
Challenge
MediBeacon required development of a wearable optical detection system capable of monitoring fluorescent tracer signals through human tissue. The system needed to achieve high sensitivity and accuracy while remaining comfortable and practical for clinical use.
In addition to performance requirements, the device needed to meet strict constraints related to cost, usability, and manufacturability. The development effort required careful balancing of optical performance, ergonomic design, and regulatory compliance within a wearable form factor.
Transdermal GFR Measurement
Overview
MediBeacon partnered with Triple Ring to develop a photonics-based transdermal detection system designed to measure kidney function using fluorescent tracer technology. The system enables non-invasive monitoring of intravenously injected tracers to generate clinically actionable measurements of glomerular filtration rate (GFR).
The resulting wearable detection platform integrates optical sensing and physiological measurement technologies to support real-time kidney function assessment in clinical environments.
Challenge
MediBeacon required development of a wearable optical detection system capable of monitoring fluorescent tracer signals through human tissue. The system needed to achieve high sensitivity and accuracy while remaining comfortable and practical for clinical use.
In addition to performance requirements, the device needed to meet strict constraints related to cost, usability, and manufacturability. The development effort required careful balancing of optical performance, ergonomic design, and regulatory compliance within a wearable form factor.
Client
MediBeacon
Practice Areas
Core Disciplines
Solution
Triple Ring collaborated closely with MediBeacon to design and deliver a non-invasive wearable detection system capable of supporting accurate GFR measurement. The development effort leveraged expertise in light-based tissue analysis and system-level modeling to optimize detection performance while supporting user comfort and clinical usability.
The team addressed these challenges by:
- Applying advanced photonics expertise to optimize signal detection through tissue
- Using modeling and simulation tools to refine optical system performance
- Designing wearable hardware that supported patient comfort during extended use
- Aligning development processes with clinical validation and regulatory expectations
Outcome
Fully integrated wearable GFR detection systems were developed under ISO 13485 design controls and delivered to support critical clinical trials. The resulting devices enabled accurate, non-invasive measurement of kidney function through optical detection of fluorescent tracers.
The platform supported the advancement of MediBeacon’s GFR monitoring technology toward clinical validation, enabling real-time physiological measurement while maintaining patient comfort and usability.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined photonics, transdermal optical sensing, wearable device design, and advanced simulation expertise to develop a clinical-grade wearable system capable of measuring kidney function non-invasively through fluorescent tracer detection.
Gus and Ed collaborated with many talented colleagues across Triple Ring and MediBeacon on this project.
Gus Lowell
Systems Architecture & Electrical Engineering
Augustus “Gus” Lowell defines the architecture of complex software and hardware systems across multidisciplinary programs. His work establishes the frameworks that connect data processing, control, and safety-critical functions, helping ensure technologies operate reliably as integrated systems.
Ed Solomon
Electrical Engineering & Advanced Technologies
Ed Solomon connects advanced engineering with business strategy to help bring innovative technologies into practical use. His work supports system architecture, partnership development, and technology adoption, helping organizations move complex ideas toward successful deployment.
Key Innovation
By taking a simulation-driven approach to x-ray source and robotic integration, we accelerated a novel intraoperative radiation therapy system from concept to FDA clearance.
Robotic Radiation Therapy
Client
Empyrean Medical Systems
Practice Areas
Core Disciplines
Overview
Empyrean Medical Systems worked with Triple Ring to design and develop a compact, robotically guided intra-operative radiation therapy device. The system was engineered to deliver targeted radiation therapy within surgical environments while maintaining a strong focus on usability and patient-centered design.
The resulting platform combined robotic guidance, precision radiation delivery, and mobile system architecture to support flexible clinical workflows and improve intra-operative treatment capabilities.
Challenge
Empyrean required development of a compact, mobile radiation therapy system capable of delivering low-energy radiation with precise beam directionality during surgical procedures. The system needed to maintain high performance standards while remaining easy to operate within the constraints of clinical environments.
In addition to performance requirements, the platform required integration of multiple complex subsystems, including custom x-ray sources, beam steering electronics, and robotic positioning components. The development effort also required preparation of a complete design package supporting regulatory submission.
Robotic Radiation Therapy
Overview
Empyrean Medical Systems worked with Triple Ring to design and develop a compact, robotically guided intra-operative radiation therapy device. The system was engineered to deliver targeted radiation therapy within surgical environments while maintaining a strong focus on usability and patient-centered design.
The resulting platform combined robotic guidance, precision radiation delivery, and mobile system architecture to support flexible clinical workflows and improve intra-operative treatment capabilities.
Challenge
Empyrean required development of a compact, mobile radiation therapy system capable of delivering low-energy radiation with precise beam directionality during surgical procedures. The system needed to maintain high performance standards while remaining easy to operate within the constraints of clinical environments.
In addition to performance requirements, the platform required integration of multiple complex subsystems, including custom x-ray sources, beam steering electronics, and robotic positioning components. The development effort also required preparation of a complete design package supporting regulatory submission.
Client
Empyrean Medical Systems
Practice Areas
Core Disciplines
Solution
Triple Ring collaborated with Empyrean throughout the full product development lifecycle, from concept generation through system integration and clinical validation. The engineering effort focused on delivering precise radiation delivery capabilities while maintaining usability and manufacturability.
Development priorities included:
- Designing custom x-ray source technologies supporting 3D beam directionality
- Applying Monte Carlo simulations to validate radiation delivery performance
- Integrating robotic motion systems supporting accurate positioning
- Preparing documentation supporting FDA regulatory submission
Outcome
Triple Ring delivered a fully integrated radiation therapy system that was verified, clinically validated, and submitted to the U.S. Food and Drug Administration (FDA) for 510(k) clearance. The resulting platform supported regulatory approval and demonstrated reliable clinical performance.
Following regulatory submission, the system design was successfully transferred to manufacturing and launched into the market. The completed platform enabled advancement of intra-operative radiation therapy capabilities and supported commercialization of the robotic radiation delivery system.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined radiation physics, custom x-ray source development, robotic systems integration, and regulatory engineering expertise to deliver a fully verified, FDA-submitted intra-operative radiation therapy platform from concept through market launch.
Chris and Barry collaborated with many talented colleagues across Triple Ring and Empyrean Medical Systems on this project.
Chris Mitchell, PhD
Bio and Electrical Engineering & Program Management
Dr. Chris Mitchell brings deep experience leading multidisciplinary teams developing complex imaging and medical device systems. His work focuses on guiding technical programs from concept through implementation, helping translate advanced technologies into reliable, real-world solutions.
Barry Wood
Biomedical & Mechanical Engineering
Barry Wood develops mechanical and biomedical systems with a focus on design and performance analysis. His work supports the creation of robust solutions for complex applications, contributing to dependable system function from concept through implementation.
Key Innovation
By translating precision pressure requirements across diverse skin types into a manufacturable applicator, we produced a home device robust enough for daily self-use.
Microneedle Patch Applicator
Client
Confidential
Practice Areas
Core Disciplines
Overview
The client selected Triple Ring to design a reusable applicator supporting the delivery of a novel micro-needle patch for transdermal drug administration. The system was intended for patient-administered use in home settings and required consistent mechanical performance to ensure reliable drug delivery.
The resulting combination product integrated a reusable applicator with a micro-needle patch system designed to enable uniform pressure application, supporting consistent adhesion and controlled dosing across diverse patient populations.
Challenge
The client developed a microneedle-based transdermal patch that required significantly greater uniformity of application pressure compared to traditional adhesive patches. Achieving reliable drug delivery required development of a reusable applicator capable of delivering consistent mechanical force during use.
The applicator needed to function effectively across a wide range of skin types, including variations in thickness, age, moisture content, and anatomical placement. In addition to performance requirements, the design needed to meet durability expectations for repeated home use while maintaining low production cost.
Microneedle Patch Applicator
Overview
The client selected Triple Ring to design a reusable applicator supporting the delivery of a novel micro-needle patch for transdermal drug administration. The system was intended for patient-administered use in home settings and required consistent mechanical performance to ensure reliable drug delivery.
The resulting combination product integrated a reusable applicator with a micro-needle patch system designed to enable uniform pressure application, supporting consistent adhesion and controlled dosing across diverse patient populations.
Challenge
The client developed a microneedle-based transdermal patch that required significantly greater uniformity of application pressure compared to traditional adhesive patches. Achieving reliable drug delivery required development of a reusable applicator capable of delivering consistent mechanical force during use.
The applicator needed to function effectively across a wide range of skin types, including variations in thickness, age, moisture content, and anatomical placement. In addition to performance requirements, the design needed to meet durability expectations for repeated home use while maintaining low production cost.
Client
Confidential
Practice Areas
Core Disciplines
Solution
Triple Ring applied interdisciplinary expertise across materials science, mechanical engineering, and life sciences to design an applicator capable of delivering controlled pressure during patch placement. The development effort focused on optimizing performance across diverse user conditions while maintaining manufacturability and reliability.
Key development efforts included:
- Designing precision mechanical systems capable of delivering uniform pressure during patch application
- Selecting materials optimized for durability, manufacturability, and patient-safe use
- Engineering applicator geometry to accommodate variation in skin thickness, moisture, and elasticity
- Validating device performance across simulated patient-use conditions
Outcome
Triple Ring delivered a reusable applicator integrated with a micro-needle array patch, forming a single-entity combination product designed for intracutaneous drug delivery. The system enabled rapid drug absorption while supporting consistent dosing performance.
The completed applicator enabled the client to advance into clinical trials and demonstrate the effectiveness of the technology to healthcare stakeholders. The underlying technology was ultimately acquired by a vaccine manufacturer, supporting continued development and commercialization.
Triple Ring Talent
The Story Behind the Innovation
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined mechanical engineering, materials science, and life sciences expertise to design a reusable applicator capable of delivering consistent, uniform pressure across diverse patient skin types — enabling reliable transdermal drug delivery in home settings.
Walt and Gabe collaborated with many talented colleagues across Triple Ring on this project.
Walt Cecka
Medical Device Design & Translational Medicine
Walt Cecka brings decades of experience translating novel medical technologies into first-to-market products. He works closely with innovators to shape early concepts into structured development programs that advance patient care across a wide range of clinical applications.
Gabriel Chow, PhD
Materials Characterization & Development
Dr. Gabe Chow specializes in materials characterization and mechanical system development across macro to nanoscale environments. His work supports the design, testing, and reliability of advanced materials and mechanical systems, helping translate innovative concepts into durable, real-world solutions.