Key Innovation
Closed-loop microfluidics cut the cost and complexity of cell therapy manufacturing.
Closed-Loop Cell Therapy Manufacturing
Client
Scaled Cell Solutions
Practice Areas
TechBio & Life Sciences
Core Disciplines
Overview
Scaled Cell Solutions, a venture-backed startup, engaged Triple Ring to rethink cell therapy manufacturing with the aims of reducing cost, shortening time to dose, and expanding patient access. By Integrating a ground-breaking workflow, biophysical analysis, and novel gene delivery technology, our work built a foundation for disrupting cell therapy production.
Challenge
Current cell therapy manufacturing processes rely on technologies that introduce risk at every step as cells are transferred between functional modules within complex, high-cost workflows. These fragmented processes resist automation, increase variability, add contamination risk, and limit patient access to potentially life-saving therapies.
Triple Ring invented a closed-loop approach that reduces complexity, lowers cost, and shortens time to dose while maintaining safety, efficacy, and product quality.
Closed-Loop Cell Therapy Manufacturing
Overview
Scaled Cell Solutions, a venture-backed startup, engaged Triple Ring to rethink cell therapy manufacturing with the aims of reducing cost, shortening time to dose, and expanding patient access. By Integrating a ground-breaking workflow, biophysical analysis, and novel gene delivery technology, our work built a foundation for disrupting cell therapy production.
Challenge
Current cell therapy manufacturing processes rely on technologies that introduce risk at every step as cells are transferred between functional modules within complex, high-cost workflows. These fragmented processes resist automation, increase variability, add contamination risk, and limit patient access to potentially life-saving therapies.
Triple Ring invented a closed-loop approach that reduces complexity, lowers cost, and shortens time to dose while maintaining safety, efficacy, and product quality.
Client
Scaled Cell Solutions
Practice Areas
TechBio & Life Sciences
Core Disciplines
Molecular & Cell Biology
Systems Engineering
Applied Physics
Microfluidics
Solution
Triple Ring developed enabling technologies designed to streamline and modernize cell therapy manufacturing through an integrated closed-loop architecture.
The solution combined several novel technologies:
- A microfluidic-based end-to-end manufacturing platform
- Modular high-throughput cell selection technology
- Advanced non-viral gene transfer technologies
- Modular subsystems capable of operating independently or within an integrated workflow
Outcome
Triple Ring developed innovative technologies that advanced cell therapy manufacturing through a microfluidic-enabled, closed-loop, end-to-end production platform.
The system eliminates cold-chain storage challenges, reduces extensive quality control measures, and shortens patient wait times. The system architecture represents a significant advancement over traditional cell therapy manufacturing approaches, whose complex and costly workflows continue to limit patient access.
Importantly, the modular cell selection and transfection subsystems operate independently or in tandem, providing flexibility for both early research and later clinical applications. The functionality of the system was successfully demonstrated at the prototype level.
Triple Ring Talent
The Story Behind the Collaboration
At Triple Ring, we draw on a deep bench of expertise across diverse disciplines matched to each innovation challenge. For this project, our team combined cell biology, microfluidics, gene delivery, bioprocess engineering, and systems integration expertise to invent a closed-loop manufacturing platform with the potential to transform patient access to cell therapies.
Gene, Roger, and Ryan collaborated with many talented colleagues across Triple Ring and Scaled Cell Solutions on this project.
Gene Napolitano, PhD
Molecular Cell Biology
Dr. Gene Napolitano brings scientific leadership to drug discovery and in vitro diagnostics programs. His work connects expertise in cell and molecular biology with diagnostic and therapeutic development across a broad range of disease areas.
Roger Tang, PhD
Bioinstrumentation and Product Development
Dr. Roger Tang leads the development of complex medical technologies spanning bioengineering, instrumentation, and applied science. His work brings together scientific, engineering, and product development expertise to guide technologies from early concept through commercialization.
Ryan McGuinness
Biotechnology and Product Development
Ryan McGuinness connects innovators, technologies, and strategic partners to accelerate the development of novel healthcare technologies. His work helps organizations build the technical, commercial, and funding foundations needed to move promising ideas toward commercialization.
